THIS FILE INCLUDES:                              
 
1.  INFORMATION ON NCBI CD-ROM PRODUCTS                  
2.  GOVERNMENT PRINTING OFFICE ORDER FORM      
 
 
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The National Center for Biotechnology Information (NCBI) builds, maintains,
and distributes the GenBank DNA sequence database.  NCBI also provides
CD-ROM versions of GenBank data integrated with bibliographic data and
sequences from other sequence databases.
 
Three CD-ROM products are produced by NCBI and are available for sale
through the US Government Printing Office (GPO).  The first CD-ROM product,
Entrez:  Sequences, contains molecular sequence databases and MEDLINE
sequence-related data, plus retrieval software, for users with Macintosh and
PC-compatible computers running Microsoft Windows.  The second product,
NCBI-GenBank (flat file format) contains GenBank data in conventional flat
file format, the same format in which the data has been traditionally
distributed.  The third CD-ROM, NCBI-Sequences (ASN.1) contains sequences in
a standard data description language format, ASN.1.  Each of the three titles
is in ISO 9660 format and is described in greater detail below.
 
The CD-ROMs are available by subscription through the Government
Printing Office (GPO).  U.S. prices are $76 for an annual subscription
to Entrez:Sequences and $47 for the each of the other disks.  An annual
subscription consists of six releases per year. Orders may be submitted
using the order form below.
 
1. Entrez: Sequences
 
Entrez: Sequences is a two disc CD-ROM set with retrieval software. The
sequences disc contains DNA and protein sequence data integrated from a
variety of sources, including GenBank, EMBL, DDBJ, PIR, Swiss-Prot, PRF and
PDB.  The reference disc contains the Molecular Biology Data subset of
MEDLINE.  The DNA sequences, protein sequences and the bibliographic
information are linked to provide easy traversal among the three types of
data. The retrieval system allows for traditional keyword searching and also
uses pre-computed statistical measures of relatedness to allow queries that
will find all the articles or sequences similar to an article or sequence of
interest.
 
Entrez: Sequences contains retrieval software for the Macintosh and for
PC-compatible systems running Microsoft Windows (3.1 or later).  A minimum
of 2 Mbytes of memory is necessary. A user's guide provides installation and
operating instructions.  Executables for an X11 version of the software for
several Unix platforms are available through anonymous FTP from
'ncbi.nlm.nih.gov' in the 'entrez/cuurent' directory.  Executables for
several DEC platforms are available through anonymous FTP from
'ncbi.wi.mit.edu' in the 'entrez.dir' directory. 
 
Please note that direct network access to Entrez is also available at no
charge. Network Entrez requires direct TCP/IP access to the Internet and a
local systems administrator to install the software and provide end-user
support.  If you are interested in Network Entrez, the designated
administrator should contact NCBI at 'net-info@ncbi.nlm.nih.gov'.
        
2. NCBI-GenBank (Flat File Format)
 
This CD-ROM provides GenBank data in the standard flat file format.  Each
release is cumulative, incorporating all previous GenBank data supplemented
by new data from direct submissions, NCBI journal scanning, and the EMBL and
DDBJ DNA databases. Conceptual translations of coding regions appear in
feature tables. The release contains the standard index files (accession
numbers, authors, keywords, gene names, citations).  No retrieval software
is provided.
 
3. NCBI-Sequences (ASN.1)
 
This title provides the integrated nucleotide and protein sequence datasets
used on the Entrez:  Sequences CD-ROM in the ISO ASN.1 standard data
description format. DNA and protein sequence data are incorporated
non-redundantly from GenBank, EMBL, DDBJ, PIR, Swiss-PROT, PRF and PDB, and
contain MEDLINE UID numbers to link to MEDLINE records. Files are provided
which contain the inter-sequence linkage information and indices to the byte
offsets of the beginning of sequence records. No retrieval software is
provided. This title is intended for software developers, not end-users.
 
 
Software Developers            
 
Software developers are advised to contact NCBI via e-mail at
'toolbox@ncbi.nlm.nih.gov' to obtain more information concerning data
formats and the availability of software tools and libraries for
applications development.  Software for manipulating ASN.1 data
structures is available through anonymous FTP from 'ncbi.nlm.nih.gov'
in the 'toolbox' directory.
 
 
Ordering Information
 
GPO will handle all subscriptions and subscription-related questions.
Telephone orders can be placed at (202) 783-3238.  Due to the high volume of
telephone ordering, GPO encourages ordering by fax or mail.  Quantity
discounts of 25% are available for orders of 100 or more CD-ROMs delivered
to a single address. We strongly recommend that you use a check, money order
or credit card to order NCBI CD-ROM products. If you absolutely must use a
purchase order, you will need prior approval from the Government Printing
Office (GPO). To obtain the necessary approval, call GPO at (202)512-2268 and
request "Fill and Bill Application Form #3695".
 
 
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       Superintendent of Documents CD-ROM Subscription Order Form
 
 Order processing code:                           To fax your orders:
 # 5403                                                 (202)512-2233
 
|_| YES, enter my order as follows:
 
  ___ subscriptions to ENTREZ: Sequences on CD-ROM (ENT)
 
  ___ subscriptions to NCBI-GenBank (Flat File) on CD-ROM (NCBIF)
      
  ___ subscriptions to NCBI-Sequences (ASN.1) on CD-ROM (NCBIA)
      
 
The total cost of my order is         For privacy protection, check the box
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and handling and is subject to        |_| Do not make my name available to
change.                                   other mailers.
 
 
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___________________________________   Mail To:  Superintendent of Documents
(Purchase Order No. for pre-approved            P.O. Box 371954
"Fill and Bill" customers only)                 Pittsburgh, PA 15250-7954
               
To open a fill and bill acct.,your
billing office must complete Fill and
Bill Application Form #3695.  To 
obtain a fill and bill application
form call (202)512-2268.
 
 
     One Year Subscription Prices (six issues) Including Delivery
____________________________________________________________________________
   Location                           Entrez:          NCBI           NCBI
                                     Sequences        GenBank      Sequences
   
United States..........................$76.00.........$47.00........$47.00
 
Zone 1 (South America).................$87.74.........$67.47........$67.47
Zone 2 (Europe)........................$97.94.........$70.79........$70.79
Zone 3 (Middle East and Africa).......$106.94.........$73.79........$73.79
Zone 4 (Asia, the Pacific, Australia).$107.66.........$74.15........$74.15
Canada.................................$84.80.........$64.67........$64.67
Mexico.................................$84.98.........$64.79........$64.79
 
     U.S. delivery via first class mail. Foreign delivery via air mail.
